Journal
AMERICAN JOURNAL OF SPORTS MEDICINE
Volume 45, Issue 9, Pages 2019-2027Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0363546517703336
Keywords
rabbit; rotator cuff; supraspinatus; atelocollagen; healing
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Funding
- Korea Health Technology R&D Project - Ministry of Health & Welfare, Republic of Korea [HI13C1501]
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Background: Failure of rotator cuff healing is a common complication despite the rapid development of surgical repair techniques for the torn rotator cuff. Purpose: To verify the effect of atelocollagen on tendon-to-bone healing in the rabbit supraspinatus tendon compared with conventional cuff repair. Study Design: Controlled laboratory study. Methods: A tear of the supraspinatus tendon was created and repaired in 46 New Zealand White rabbits. They were then randomly allocated into 2 groups (23 rabbits per group; 15 for histological and 8 for biomechanical test). In the experimental group, patch-type atelocollagen was implanted between bone and tendon during repair; in the control group, the torn tendon was repaired without atelocollagen. Each opposite shoulder served as a sham (tendon was exposed only). Histological evaluation was performed at 4, 8, and 12 weeks. Biomechanical tensile strength was tested 12 weeks after surgery. Results: Histological evaluation scores of the experimental group (4.0 +/- 1.0) were significantly superior to those of the control group (7.7 +/- 2.7) at 12 weeks (P = .005). The load to failure was significantly higher in the experimental group (51.4 +/- 3.9 N) than in the control group (36.4 +/- 5.9 N) (P = .001). Conclusion: Histological and biomechanical studies demonstrated better results in the experimental group using atelocollagen in a rabbit model of the supraspinatus tendon tear.
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