Journal
ACS CATALYSIS
Volume 7, Issue 6, Pages 4138-4143Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b01072
Keywords
C-H benzylation; Ruthenium Catalyst; Oxidative Cross-coupling; Regioselectivity
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Funding
- Natural Science Foundation of China [21572149]
- Young National Natural Science Foundation of China [21402133, 21403148]
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A Ru-catalyzed 1,1'-binaphthyl-2,2'-diylhydrogen phosphate (BNDHP)-enabled meta C-H benzylation under the assistance of ferrocene using less sterically hindered toluene derivatives as the coupling partners has been developed. Various arenes bearing pyridyl, pyridmidyl, and pyrazolyl directing groups can be selectively coupled with toluenes at the meta positions in moderate to good yield. A mechanistic study clearly showed the site selectivity at the ortho or meta position is completely controlled by the ligand of BNDHP and the catalyst precursor.
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