Journal
ACS CATALYSIS
Volume 7, Issue 4, Pages 2583-2596Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b03663
Keywords
organocatalysis; enantioselective catalysis; N-heterocyclic carbene catalysis; Lewis-base catalysis; reaction cascade
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- ARC
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First reported less than a decade ago, the alpha,beta-unsaturated acyl azolium has emerged as a central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis. In this Perspective, an introduction to the four main reactivity patterns accessible from this intermediate is provided. The Perspective is handled in a largely chronological fashion, with an emphasis on alternate approaches to the key intermediate and first-in-class reaction cascades. Finally, a brief discussion of emerging trends in this field of catalysis is presented. Although not exhaustive, the NHC Perspective provides an overview of this active area of research and serves as a guide for future investigations.
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