Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-00180-9
Keywords
-
Categories
Funding
- Neuro-Electronics Research Flanders
- AIHS Polaris award
- AIHS graduate studentship
- NSERC
- NSF [1631465]
- Research Foundation-Flanders (FWO) [G0D0516N]
- KU Leuven Research Council [C14/16/048]
- Alberta Innovates [201300159] Funding Source: researchfish
- Direct For Social, Behav & Economic Scie [1631465] Funding Source: National Science Foundation
- Division Of Behavioral and Cognitive Sci [1631465] Funding Source: National Science Foundation
Ask authors/readers for more resources
Sparse orthogonal coding is a key feature of hippocampal neural activity, which is believed to increase episodic memory capacity and to assist in navigation. Some retrosplenial cortex (RSC) neurons convey distributed spatial and navigational signals, but place-field representations such as observed in the hippocampus have not been reported. Combining cellular Ca2+ imaging in RSC of mice with a head-fixed locomotion assay, we identified a population of RSC neurons, located predominantly in superficial layers, whose ensemble activity closely resembles that of hippocampal CA1 place cells during the same task. Like CA1 place cells, these RSC neurons fire in sequences during movement, and show narrowly tuned firing fields that form a sparse, orthogonal code correlated with location. RSC 'place' cell activity is robust to environmental manipulations, showing partial remapping similar to that observed in CA1. This population code for spatial context may assist the RSC in its role in memory and/or navigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available