Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 8, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00739-17
Keywords
soraphen A; HIV; fatty acid synthesis; host factor; broad-spectrum antiviral; human immunodeficiency virus
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Funding
- FPI from Spanish Ministry of Economy, Industry and Competitiveness [BES-2011-048569, SAF2013-46077-R, SAF2016-75505-R, BFU2016-80039-R]
- FEDER (AEI/MINEICO/FEDER, UE)
- Maria de Maeztu Programme for Units of Excellence in RD [MDM-2014-0370]
- German Centre for Infection Research (DZIF)
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Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.
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