Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms14318
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Funding
- MEXT/JSPS KAKENHI [JP26113507, JP26291057, JP16H01237, JP25114511, JP26113707, JP16H01462, JP25221105, JP15H05957, JP26113520, JP16H01234, JP25840111]
- Howard Hughes Medical Institute (HHMI)
- Gordon and Betty Moore Foundation (GBMF) [GBMF3035]
- Grants-in-Aid for Scientific Research [14J08452, 16H01462, 25840111, 15H05957, 26291057, 16H01237, 15F15778, 16H01234] Funding Source: KAKEN
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Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.
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