Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15845
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Funding
- Claire Giannini Fund
- United States Air Force [FA9550-15-1-0007]
- National Institutes of Health [NIH DP50D012179]
- National Science Foundation [NSF 1438340]
- Damon Runyon Cancer Research Foundation (DFS) [06-13]
- Susan G. Komen Breast Cancer Foundation [SAB15-00003]
- Mary Kay Foundation [017-14]
- Donald E. and Delia B. Baxter Foundation
- Skippy Frank Foundation
- Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) [NIH-NCI U54CA151459]
- Stanford Bio-X Interdisciplinary Initiative Program [IIP6-43]
- Pew Charitable Trusts
- Alexander and Margaret Stewart Trust
- Stanford Bowes Bio-X Graduate Fellowship
- Stanford Biophysics Program training grant [T32 GM-08294]
- NIH [NS069375]
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Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution. Using SM-OCT, we reveal small structures in the tissues of living animals, such as the inner stromal structure of a live mouse cornea, the fine structures inside the mouse pinna, and sweat ducts and Meissner's corpuscle in the human fingertip skin-features that are otherwise obscured by speckle noise when using conventional OCT or OCT with current state of the art speckle reduction methods.
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