Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-02255-z
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Funding
- National Natural Science Foundation of China [31400678, 31470240, 31500642, 31570130, 31600058, 31600638]
- CAS Interdisciplinary Innovation Team
- Youth Innovation Promotion Association CAS
- Taiwan Protein Project [MOST105-0210-01-12-01, MOST106-0210-01-15-04]
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PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Through structural analyses, mutagenesis, and activity measurements, a substrate-binding mode is proposed, and several features critical for catalysis are elucidated.
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