Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13998
Keywords
-
Categories
Funding
- GEFLUC Paris-Ile de France 'Les entreprises contre le cancer'
- 'Fondation pour la Recherche Medicale'
- 'Association pour la Recherche contre le Cancer'
- 'La Ligue, Comite de Paris', 'Initiatives d'excellence' [Idex ANR-11-IDEX-0005-02)- Labex, ANR- 11- LABX- 0071]
- Assistance Publique-Hopitaux de Paris, AP-HP' (Projets Hospitaliers de Recherche Clinique (PHRC) grants)
Ask authors/readers for more resources
Monolayered epithelia are composed of tight cell assemblies that ensure polarized exchanges. EpCAM, an unconventional epithelial-specific cell adhesion molecule, is assumed to modulate epithelial morphogenesis in animal models, but little is known regarding its cellular functions. Inspired by the characterization of cellular defects in a rare EpCAM-related human intestinal disease, we find that the absence of EpCAM in enterocytes results in an aberrant apical domain. In the course of this pathological state, apical translocation towards tricellular contacts (TCs) occurs with striking tight junction belt displacement. These unusual cell organization and intestinal tissue defects are driven by the loss of actomyosin network homoeostasis and contractile activity clustering at TCs, yet is reversed by myosin-II inhibitor treatment. This study reveals that adequate distribution of cortical tension is crucial for individual cell organization, but also for epithelial monolayer maintenance. Our data suggest that EpCAM modulation protects against epithelial dysplasia and stabilizes human tissue architecture.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available