Journal
CELL CYCLE
Volume 16, Issue 13, Pages 1295-1301Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1317416
Keywords
lnc-sox5; colorectal cancer (CRC); Indoleamine 2; 3-dioxygenase 1 (IDO1); long non-coding RNA; Tregs; tumor microenvironment
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Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3(+)CD8(+)T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.
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