Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15757
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Funding
- European Union's Horizon European Research Council (ERC Consolidator Grant) [682574]
- Swiss National Science Foundation [PP00P2_133562]
- Centre d'Imagerie BioMedicale (CIBM) of the UNIL
- UNIGE
- HUG
- CHUV
- EPFL
- Leenards Foundation
- Jeantet Foundation
- European Research Council (ERC) [682574] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [PP00P2_133562] Funding Source: Swiss National Science Foundation (SNF)
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Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time C-13 MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together with the constraint of having to polarize the C-13 spins in a dedicated apparatus nearby but separated from the MRI magnet. We herein demonstrate that by polarizing C-13 with photo-induced radicals, which can be subsequently annihilated using a thermalization process that maintains the sample temperature below its melting point, hyperpolarized C-13-substrates can be extracted from the DNP apparatus in the solid form, while maintaining the enhanced C-13 polarization. The melting procedure necessary to transform the frozen solid into an injectable solution containing the hyperpolarized C-13-substrates can therefore be performed ex situ, up to several hours after extraction and storage of the polarized solid.
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