Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncomms15259
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Funding
- Swedish Research Council [2013-530]
- DFG [BR 1492/7-1, TRR134]
- DFG within the Excellence Initiative by German Federal and State Governments (CECAD)
- European Union Seventh Framework Program (FP7) [266408]
- Helmholtz Alliance (Imaging and Curing Environmental Metabolic Diseases [ICEMED]) through the Initiative and Networking Fund of the Helmholtz Association
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The central nervous system (CNS) has an important role in the regulation of peripheral insulin sensitivity and glucose homeostasis. Research in this dynamically developing field has progressed rapidly due to techniques allowing targeted transgenesis and neurocircuitry mapping, which have defined the primary responsive neurons, associated molecular mechanisms and downstream neurocircuitries and processes involved. Here we review the brain regions, neurons and molecular mechanisms by which the CNS controls peripheral glucose metabolism, particularly via regulation of liver, brown adipose tissue and pancreatic function, and highlight the potential implications of these regulatory pathways in type 2 diabetes and obesity.
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