Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15475
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Funding
- Grants-in-Aid for Scientific Research [15H02755, 17K07144, 15K06815] Funding Source: KAKEN
- Medical Research Council [MC_UP_1502/3, MC_U142684172, G0300212, MC_QA137918, MC_U142684171, MR/N012119/1] Funding Source: Medline
- NCI NIH HHS [P30 CA034196] Funding Source: Medline
- NHGRI NIH HHS [UM1 HG006348] Funding Source: Medline
- NIH HHS [UM1 OD023222, UM1 OD023221, U42 OD011185, U42 OD012210] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/M02069X/1] Funding Source: researchfish
- Medical Research Council [MC_U142684172, MC_qA137918, MC_UP_1502/3, G0300212, MR/N012119/1, MC_U142684171] Funding Source: researchfish
- BBSRC [BB/M02069X/1] Funding Source: UKRI
- MRC [MC_U142684172, MC_U142684171, MR/N012119/1, G0300212, MC_qA137918, MC_UP_1502/3] Funding Source: UKRI
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The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
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