Journal
NPJ PRECISION ONCOLOGY
Volume 1, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41698-017-0031-0
Keywords
-
Categories
Funding
- National Institutes of Health [CA177909, CA016672, CA109298, UH3TR000943, P50 CA083639, P50 CA098258]
- Cancer Prevention and Research Institute of Texas [RP110595, RP120214]
- Ovarian Cancer Research Fund, Inc. (Program Project Development Grant)
- RGK Foundation
- Judi A. Rees ovarian cancer research fund
- Blanton-Davis Ovarian Cancer Research Program
- American Cancer Society Research Professor Award
- Frank McGraw Memorial Chair in Cancer Research
- Keck Center of the Gulf Coast Consortia, on the Training Program in Biomedical Informatics, National Library of Medicine (NLM) [T15LM007093]
- Ovarian Cancer Research Fund, Inc.
- Foundation for Women's Cancer
- Texas Center for Cancer Nanomedicine
- Collen's Dream Foundation
- Cancer Prevention Research Institute of Texas training grants [RP101502, RP101489]
Ask authors/readers for more resources
The immune system has many important regulatory roles in cancer development and progression. Given the emergence of effective immune therapies against many cancers, reliable predictors of response are needed. One method of determining response is by evaluating immune cell populations from treated and untreated tumor samples. The amount of material obtained from tumor biopsies can be limited; therefore, gene-based or protein-based analyses may be attractive because they require minimal tissue. Cell-specific signatures are being analyzed with use of the latest technologies, including NanoString's nCounter technology, intracellular staining flow cytometry, cytometry by time-of-flight, RNA-Seq, and barcoding antibody-based protein arrays. These signatures provide information about the contributions of specific types of immune cells to bulk tumor samples. To date, both tumor tissue and immune cells have been analyzed for molecular expression profiles that can assess genes and proteins that are specific to immune cells, yielding results of varying specificity. Here, we discuss the importance of profiling tumor tissue and immune cells to identify immune-cell-associated genes and proteins and specific gene profiles of immune cells. We also discuss the use of these signatures in cancer treatment and the challenges faced in molecular expression profiling of immune cell populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available