Journal
DEVELOPMENTAL BIOLOGY
Volume 428, Issue 2, Pages 273-282Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2017.05.015
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Funding
- VENI grant from the Netherlands Organisation for Scientific Research (NWO-ZonMW) [016.166.140]
- Human Frontier Science Program Organization (HFSPO) [LT771/2015]
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Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector beta-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.
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