Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncomms15087
Keywords
-
Categories
Funding
- French National Research Agency [ANR-14-CE14-0023-01]
- DGA-MRIS scholarship
- Provence-Alpes-Cote-d'Azur region [2010 12125]
- ProFi grant [ANR-10-INBS-08-01]
- bottom-up platform and informatics group of EDyP
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0023] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
Acanthamoeba are infected by a remarkable diversity of large dsDNA viruses, the infectious cycles of which have been characterized using genomics, transcriptomics and electron microscopy. Given their gene content and the persistence of the host nucleus throughout their infectious cycle, the Marseilleviridae were initially assumed to fully replicate in the cytoplasm. Unexpectedly, we find that their virions do not incorporate the virus-encoded transcription machinery, making their replication nucleus-dependent. However, instead of delivering their DNA to the nucleus, the Marseilleviridae initiate their replication by transiently recruiting the nuclear transcription machinery to their cytoplasmic viral factory. The nucleus recovers its integrity after becoming leaky at an early stage. This work highlights the importance of virion proteomic analyses to complement genome sequencing in the elucidation of the replication scheme and evolution of large dsDNA viruses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available