Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms14419
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Funding
- MEXT-JSPS Kakenhi [24111004, 23249025, 16H02630, 25860361, 15K19130, 25221102, 26000014]
- MEXT scholarship
- Grants-in-Aid for Scientific Research [24111004, 25860361, 15K19130, 16H02630, 23249025, 24111001, 16K08228, 26000014] Funding Source: KAKEN
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The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of beta 5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8(+) T cells. A point mutation in this genome element results in a defect in beta 5t expression and CD8(+) T-cell production in mice. The results reveal a Foxn1-beta 5t transcriptional axis that governs CD8(+) T-cell production in the thymus.
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