Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 44, Issue -, Pages 101-109Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.03.018
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Funding
- NIH [MH-60119]
- CIHR [MOP 13458, 82762, 130502]
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Electrophysiological recordings indicate that neurons which discharge maximally in association with distinct sleep-wake states are distributed through the brain, albeit in differing proportions. As studied using juxtacellular recording and labeling within the basal forebrain, four functional principal cell types are distinguished as: wake/paradoxical sleep(W/PS)-, slow wave sleep (SWS)-, W- and PS-max active. They are each comprised by both GABA and glutamate neurons, in addition to acetylcholine neurons belonging to the W/PS group. By their discharge profiles and interactions, the GABA and glutamate neurons of different groups are proposed to have the capacity to generate sleep-wake states with associated EEG and EMG activities, though to also be importantly regulated by neuromodulatory systems, each of which belong to one functional cell group.
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