Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-00715-0
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Funding
- NIH/NINDS [K99/R00, NS092972]
- Champalimaud Foundation, Portugal
- Howard Hughes Medical Institute
- Christopher and Dana Reeve Paralysis Foundation
- Burroughs Welcome Fund Career Awards in the Biomedical Sciences
- Defense Advanced Research Projects Agency Reorganization and Plasticity to Accelerate Injury Recovery [N66001-10-C-2010]
- US National Institutes of Health Institute of Neurological Disorders and Stroke Transformative Research Award [R01NS076460]
- US National Institutes of Health Director's Pioneer Award [8DP1HD075623-04]
- US National Institutes of Health Director's Transformative Research Award (TR01) from the NIMH [5R01MH09964703]
- Defense Advanced Research Projects Agency NeuroFAST award from BTO [W911NF-14-2-0013]
- Simons Foundation
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Dorsal premotor cortex is implicated in somatomotor decisions. However, we do not understand the temporal patterns and laminar organization of decision-related firing rates in dorsal premotor cortex. We recorded neurons from dorsal premotor cortex of monkeys performing a visual discrimination task with reaches as the behavioral report. We show that these neurons can be organized along a bidirectional visuomotor continuum based on taskrelated firing rates. Increased neurons at one end of the continuum increased their firing rates similar to 150 ms after stimulus onset and these firing rates covaried systematically with choice, stimulus difficulty, and reaction time-characteristics of a candidate decision variable. Decreased neurons at the other end of the continuum reduced their firing rate after stimulus onset, while perimovement neurons at the center of the continuum responded only similar to 150 ms before movement initiation. These neurons did not show decision variable-like characteristics. Increased neurons were more prevalent in superficial layers of dorsal premotor cortex; deeper layers contained more decreased and perimovement neurons. These results suggest a laminar organization for decision-related responses in dorsal premotor cortex.
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