Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 63, Pages 8906-8909Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc04092j
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Funding
- UMass Medical School (UMMS)
- UGC New Delhi
- University of Delhi
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We have synthesized and studied the biological and biophysical properties of triazole-linked ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole linkage gave high binding affinity when incorporated at the 30 or 50 termini of oligo-nucleotides, but low binding affinity at internal positions. Antisense oligonucleotides (ASOs) and siRNAs containing triazole dimers were highly active and nuclease resistant. Surprisingly, the xyloLNA-modified siRNA was the most active of the series.
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