Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 63, Pages 8910-8913Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc05159j
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Funding
- UK BBSRC [BB/J001694/2]
- Marie Sklodowska-Curie Individual Fellowship
- European Commission
- National Heart, Lung and Blood Institute, NIH, USA through the NIH-Oxford-Cambridge Research Scholars Program
- BBSRC [BB/J001694/1] Funding Source: UKRI
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Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 50-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.
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