Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 174, Issue 8, Pages 785-794Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.2017.16040464
Keywords
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Categories
Funding
- European Union [LSHM-CT-2007-037286]
- Horizon [695313]
- ERANID (Understanding the Interplay Between Cultural, Biological, and Subjective Factors in Drug Use Pathways) [PR-ST-0416-10004]
- BRIDGET (JPND: Brain Imaging, Cognition, Dementia, and Next-Generation Genomics) [MR/N027558/1]
- FP7 [602450, 603016]
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council Grant c-VEDA (Consortium on Vulnerability to Externalizing Disorders and Addictions) [MR/N000390/1]
- Swedish Research Council FORMAS
- Medical Research Council
- National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust
- King's College London
- Bundesministerium fur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, eMED SysAlc01ZX1311A, Forschungsnetz AERIAL]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-1, SM 80/7-2, SFB 940/1]
- Agence Nationale de la Recherche [AF12-NEUR0008-01-WM2NA, ANR-12-SAMA-0004]
- Fondation de France
- Fondation pour la Recherche Medicale
- Mission Interministerielle de Lutte Contre les Drogues et les Conduites Addictives (MILDECA)
- Assistance Publique Hopitaux de Paris
- INSERM (interface grant)
- Paris Sud University IDEX
- NIH [RO1 MH085772-01A1, U54 EB020403]
- cross-NIH alliance
- Eli Lilly
- Janssen McNeil
- Medice
- Novartis
- Shire
- UCB
- General Electric Healthcare
- Science Foundation Ireland Stokes Programme [07/SK/B1214a]
- Lyndra
- GlaxoSmithKline
- Agence Nationale de la Recherche (ANR) [ANR-12-SAMA-0004] Funding Source: Agence Nationale de la Recherche (ANR)
- Science Foundation Ireland (SFI) [07/SK/B1214a] Funding Source: Science Foundation Ireland (SFI)
- Medical Research Council [G9817803, MR/N000390/1, G0901858, G9817803B] Funding Source: researchfish
- MRC [G0901858, MR/N000390/1, G9817803] Funding Source: UKRI
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Objective: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships. Method: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions. Results: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdala-precuneus connectivity is associated with hyperactivity/inattention symptoms. Conclusions: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms.
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