Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15118
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Funding
- Australian Research Council Centre of Excellence Scheme [EQuS CE110001013]
- ARC [DP1094439]
- Lockheed Martin Corporation
- US Army Medical Research and Materiel Command (USAMRMC)
- Defense Medical Research and Development Program (DMRDP) award [W81XWH-11-2-0076 (DM09094)]
- US Army Research Office (ARO) Multidisciplinary University Research Initiative (MURI) [W911NF-15-1-0548]
- ANSTO
- Australian-American Fulbright Commison
- Swiss National Science Foundation [P300P2_147768]
- Australian Research Council [DP1094439] Funding Source: Australian Research Council
- Swiss National Science Foundation (SNF) [P300P2_147768] Funding Source: Swiss National Science Foundation (SNF)
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Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton-electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to H-1 spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.
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