Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-017-00212-4
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Funding
- German Research Foundation (DFG) [KL-2374/2-1]
- Madeleine Schickedanz foundation
- Clinician-Scientist Program Young Academy of the Hannover Medical School
- DFG-Cluster of excellence REBIRTH
- Hannover Biomedical Research School
- Graduate School of the University of Ulm
- Excellence Initiative of the German Federal Government
- Excellence Initiative of the German State Government
- Max-Eder program from the German Cancer Aid [109420, 111743]
- European Hematology Association [2010/04]
- DFG [SFB 1074]
- Cancer Australia
- Anthony Rothe Foundation
- Cancer Institute of New South Wales
- National Health and Medical Research Council
- European Union [282510 BLUEPRINT]
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Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are incompletely understood. Here we present a comprehensive resource defining the non-coding RNA landscape of the human hematopoietic system. Based on highly specific non-coding RNA expression portraits per blood cell population, we identify unique fingerprint non-coding RNAs-such as LINC00173 in granulocytes-and assign these to critical regulatory circuits involved in blood homeostasis. Following the incorporation of acute myeloid leukemia samples into the landscape, we further uncover prognostically relevant non-coding RNA stem cell signatures shared between acute myeloid leukemia blasts and healthy hematopoietic stem cells. Our findings highlight the importance of the non-coding transcriptome in the formation and maintenance of the human blood hierarchy.
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