Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-017-00081-x
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Funding
- Shiv Nadar University
- Early Career Research Grant from Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India [ECR/2015/000337]
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Carbonyl-carbonyl n ->pi* interactions where a lone pair (n) of the oxygen atom of a carbonyl group is delocalized over the pi* orbital of a nearby carbonyl group have attracted a lot of attention in recent years due to their ability to affect the 3D structure of small molecules, polyesters, peptides, and proteins. In this paper, we report the discovery of a reciprocal carbonyl-carbonyl interaction with substantial back and forth n ->pi* and pi ->pi* electron delocalization between neighboring carbonyl groups. We have carried out experimental studies, analyses of crystallographic databases and theoretical calculations to show the presence of this interaction in both small molecules and proteins. In proteins, these interactions are primarily found in polyproline II ( PPII) helices. As PPII are the most abundant secondary structures in unfolded proteins, we propose that these local interactions may have implications in protein folding.
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