Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15122
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Funding
- European Research Council (ERC) [I2ST 260742]
- EMBO
- Auvergne Regional Council
- Max Planck Society
- DFG [SFB 1101]
- Japan Society for the Promotion of Science (JSPS) [26891018, 15K18578]
- Program to Disseminate Tenure Tracking System, MEXT, Japan
- Ministere de l'education nationale, de l'enseignement superieur et de la recherche
- Grants-in-Aid for Scientific Research [26891018, 15K18578] Funding Source: KAKEN
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Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposon-related plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.
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