Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13724
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Funding
- National Institute of Health [HL123920]
- NC State University Chancellor's Faculty Excellence Program
- NC State Chancellor's Innovation Fund
- University of North Carolina General Assembly Research Opportunities Initiative grant
- National Natural Science Foundation of China [81370216, 81570274, 31670895, U1404802]
- Science and Technology Innovation Team Support Project of Henan Province [14IRTSTHN018]
- Innovation Team of Science and Technology Project of Henan Province [164200510012]
- China Scholarship Council
- Atomic Bomb Disease Institute at Nagasaki University, Japan
- Grants-in-Aid for Scientific Research [15K15509] Funding Source: KAKEN
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Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks. Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell-cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair. CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable myocardium and augmentation of cardiac functions similar to cardiac stem cell therapy. CMMPs (derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice. In conclusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.
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