Journal
CHEMPHOTOCHEM
Volume 1, Issue 5, Pages 183-187Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cptc.201600049
Keywords
nanoparticles; persistent luminescence; photodynamic therapy; photosensitizers; singlet oxygen
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Funding
- Bilkent University
- TUBITAK
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The broader application of photodynamic therapy as a treatment procedure for cancer is hampered by the limited penetration of light through mammalian tissues. Since the photosensitized generation of cytotoxic singlet oxygen requires effective excitation of the tumor-localized photosensitizer, photodynamic action can only be guaranteed for the first few milli-meters of the irradiated tissues. In this work, we demonstrated that the phenomenon of persistent luminescence, that is, delayed emission from certain metal-ion excited states (with crystal defects acting as energy traps), can provide an alternative excitation possibility. Thus, persistent luminescent nanoparticles functionalized by FRET-matching Bodipy sensitizers (FRET=Forster resonance energy transfer) were excited in situ before administration into a cell culture or an organism. It was found that this system continues to produce singlet oxygen regardless of their location and without any need for continuous photonic excitation.
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