Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-00971-0
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Funding
- Fulbright Scholar Program
- CONACyT Fronteras de la Ciencia [2015-02-846]
- Max Planck Institute for Biological Cybernetics
- Center of Advanced European Studies and Research
- Studienstiftung des deutschen Volkes
- Bernstein Center for Computational Neuroscience
- German Federal Ministry of Education and Research Grant [BMBF/FKZ 01GQ1002]
- European Research Council (ERC) under the European Union's Horizon research and innovation program [633428]
- Max Planck Florida Institute for Neuroscience
- European Research Council (ERC) [633428] Funding Source: European Research Council (ERC)
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Pyramidal tract neurons (PTs) represent the major output cell type of the neocortex. To investigate principles of how the results of cortical processing are broadcasted to different downstream targets thus requires experimental approaches, which provide access to the in vivo electrophysiology of PTs, whose subcortical target regions are identified. On the example of rat barrel cortex (vS1), we illustrate that retrograde tracer injections into multiple subcortical structures allow identifying the long-range axonal targets of individual in vivo recorded PTs. Here we report that soma depth and dendritic path lengths within each cortical layer of vS1, as well as spiking patterns during both periods of ongoing activity and during sensory stimulation, reflect the respective subcortical target regions of PTs. We show that these cellular properties result in a structure-function parameter space that allows predicting a PT's subcortical target region, without the need to inject multiple retrograde tracers.
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