Journal
NATURE COMMUNICATIONS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13913
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Funding
- United States NSF (Biophotonics Program)
- ONR
- ARO
- HHMI
- Swedish Research Council
- Swedish Cancer Foundation [2015/838, 2015/629]
- SciLifeLab
- IMI project OncoTrack
- United States NSF (EFRI Program)
- United States NSF (BIC Program)
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Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samples can be imaged and analysed using mobile phone microscopy, achieving a new milestone for tele-medicine technologies.
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