Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 65, Pages 9109-9112Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03241b
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Funding
- DST-SERB
- IIT KGP
- Department of Science & Technology (DST), India, for DST-INSPIRE Faculty Research project grant at CSIR-IICT, Hyderabad [GAP 0546]
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A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The locked'' FRET pair was selectively unlocked'' by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.
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