Related references
Note: Only part of the references are listed.Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase
Peter Stepper et al.
NUCLEIC ACIDS RESEARCH (2017)
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
Angelo Amabile et al.
CELL (2016)
Editing DNA Methylation in the Mammalian Genome
X. Shawn Liu et al.
CELL (2016)
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Andrew P. Feinberg et al.
NATURE REVIEWS GENETICS (2016)
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
Aleksandar Vojta et al.
NUCLEIC ACIDS RESEARCH (2016)
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India
Sarah Siddiqui et al.
BREAST CANCER (2016)
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
David Cano-Rodriguez et al.
NATURE COMMUNICATIONS (2016)
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
James I. McDonald et al.
BIOLOGY OPEN (2016)
TALE-mediated epigenetic suppression of CDKN2A increases replication in human
Diana L. Bernstein et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
Goran Kungulovski et al.
EPIGENETICS & CHROMATIN (2015)
Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer
Anna Diez-Villanueva et al.
EPIGENETICS & CHROMATIN (2015)
Luminal Progenitors Restrict Their Lineage Potential during Mammary Gland Development
Veronica Rodilla et al.
PLOS BIOLOGY (2015)
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
Robert Lowe et al.
GENOME BIOLOGY (2015)
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations
James C. Garbe et al.
CELL CYCLE (2014)
Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence
Michael D. Allen et al.
CLINICAL CANCER RESEARCH (2014)
Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice
Da-Hai Yu et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
S. C. Mack et al.
NATURE (2014)
Mammary stem cells have myoepithelial cell properties
Michael D. Prater et al.
NATURE CELL BIOLOGY (2014)
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
Andrew E. Teschendorff et al.
BIOINFORMATICS (2013)
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
Jovana Klajic et al.
BMC CANCER (2013)
Assessment of DNA methylation status in early stages of breast cancer development
A. Q. van Hoesel et al.
BRITISH JOURNAL OF CANCER (2013)
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
Christin E. Burd et al.
CELL (2013)
Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity
Abu Nasar Siddique et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Kevin M. Esvelt et al.
NATURE METHODS (2013)
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival
Daniel D. De Carvalho et al.
CANCER CELL (2012)
p16 promoter hypermethylation is associated with increased breast cancer risk
Li Wang et al.
MOLECULAR MEDICINE REPORTS (2012)
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Peter A. Jones
NATURE REVIEWS GENETICS (2012)
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis
Warwick J. Locke et al.
BREAST CANCER RESEARCH (2012)
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang et al.
NATURE (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Association of sporadic breast cancer with PTEN/MMAC1/TEP1 promoter hypermethylation
Vallian Sadeq et al.
MEDICAL ONCOLOGY (2011)
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
Aslaug Aa Muggerud et al.
BREAST CANCER RESEARCH (2010)
Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization
Petr Novak et al.
CANCER RESEARCH (2009)
Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning
Rebecca A. Hinshelwood et al.
HUMAN MOLECULAR GENETICS (2009)
Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus
Alexander E. Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase
Wataru Nomura et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
Kei Haga et al.
CANCER SCIENCE (2007)
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells
Paul A. Reynolds et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant program
YG Crawford et al.
CANCER CELL (2004)
The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis
NE Sharpless et al.
ONCOGENE (2004)
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis
TD Tlsty et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2004)
DNA methylation of RASSF1A, Hin-1, RAR-β, cyclin D2 and twist in in situ and invasive lobular breast carcinoma
MJ Fackler et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Distinct methylation profiles of glioma subtypes
K Uhlmann et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
M Esteller
ONCOGENE (2002)
The human genome browser at UCSC
WJ Kent et al.
GENOME RESEARCH (2002)
Quantitative assessment of promoter hypermethylation during breast cancer development
U Lehmann et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
NE Sharpless et al.
NATURE (2001)
A new mathematical model for relative quantification in real-time RT-PCR
MW Pfaffl
NUCLEIC ACIDS RESEARCH (2001)
Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence
TD Tlsty et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2001)
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
SR Romanov et al.
NATURE (2001)
Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells
MJ O'Hare et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
JF Costello et al.
NATURE GENETICS (2000)