Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 35, Pages 10378-10382Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201704196
Keywords
C-H activation; cobalt; hydroarylation; reaction mechanism; selectivity
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Funding
- DFG [SPP 1807]
- European Research Council under the European Community's Seventh Framework Program (FP7)/ERC [307535]
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Selectivity control in hydroarylation-based C-H alkylation has been dominated by steric interactions. A conceptually distinct strategy that exploits the programmed switch in the C-H activation mechanism by means of cobalt catalysis is presented, which sets the stage for convenient C-H alkylations with unactivated alkenes. Detailed mechanistic studies provide compelling evidence for a programmable switch in the C-H activation mechanism from, a linear-selective ligand-to-ligand hydrogen transfer to a branched-selective base-assisted internal eleetrophilic-type substitution.
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