Journal
ONCOLOGY LETTERS
Volume 13, Issue 4, Pages 2449-2453Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.5733
Keywords
DNA methylation; protocadherin 10; tumor suppressor gene; colorectal cancer; tumor biomarker
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Funding
- Health Program of Hangzhou [20140633B26]
- National Natural Science Foundation of China [81000945, 81071619, 81101477]
- Zhejiang Provincial Natural Science Foundation of China [Y2110018]
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Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inactivation of tumor suppressor genes (TSGs) through promoter methylation serves an important role. Aberrant methylation is a well-defined marker of CRC. At present, the epigenetic silencing of protocadherin 10 (PCDH10) has been identified as an important TSG with key roles in colorectal carcinogenesis, invasion and metastasis as a frequent and early event. Advances in gene methylation detection in tumor tissues and body fluids have led to the development of non-invasive screening methods for CRC. The present study aimed to review the epigenetic alteration of PCDH10 in CRC development, and the potential of PCDH10 to be a non-invasive biomarker for CRC.
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