Journal
ANAIS BRASILEIROS DE DERMATOLOGIA
Volume 92, Issue 3, Pages 356-362Publisher
ELSEVIER SCIENCE INC
DOI: 10.1590/abd1806-4841.20175697
Keywords
Antioxidants; Carotenoids; Dermatitis; DNA damage; Free radicals; Polypodium; Skin aging
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The skin cells continuously produce, through cellular respiration, metabolic processes or under external aggressions, highly reactive molecules oxidation products, generally called free radicals. These molecules are immediately neutralized by enzymatic and non-enzymatic systems in a physiological and dynamic balance. In situations where this balance is broken, various cellular structures, such as the cell membrane, nuclear or mitochondrial DNA may suffer structural modifications, triggering or worsening skin diseases. several substances with alleged antioxidant effects has been offered for topical or oral use, but little is known about their safety, possible associations and especially their mechanism of action. The management of topical and oral antioxidants can help dermatologist to intervene in the oxidative processes safely and effectively, since they know the mechanisms, limitations and potential risks of using these molecules as well as the potential benefits of available associations.
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