4.6 Article

Lateral Tension-Induced Penetration of Particles into a Liposome

Journal

MATERIALS
Volume 10, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/ma10070765

Keywords

particle penetration; lateral tension; lipid membrane; gene delivery method

Funding

  1. AMED-CREST
  2. AMED
  3. MEXT KAKENHI [15H00807, 26103516]
  4. JSPS KAKENHI [15K12538, 26610112]
  5. SUNBOR SCHOLARSHIP from SUNTORY FOUNDATION FOR LIFE SCIENCE
  6. Grants-in-Aid for Scientific Research [26103516, 15K12538, 26610112] Funding Source: KAKEN

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It is important that we understand the mechanism of the penetration of particles into a living cell to achieve advances in bionanotechnology, such as for treatment, visualization within a cell, and genetic modification. Although there have been many studies on the application of functional particles to cells, the basic mechanism of penetration across a biological membrane is still poorly understood. Here we used a model membrane system to demonstrate that lateral membrane tension drives particle penetration across a lipid bilayer. After the application of osmotic pressure, fully wrapped particles on a liposome surface were found to enter the liposome. We discuss the mechanism of the tension-induced penetration in terms of narrow constriction of the membrane at the neck part. The present findings are expected to provide insight into the application of particles to biological systems.

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