Journal
ANNALS OF CARDIOTHORACIC SURGERY
Volume 6, Issue 4, Pages 353-363Publisher
AME PUBL CO
DOI: 10.21037/acs.2017.07.07
Keywords
Hypertrophic cardiomyopathy (HCM); myectomy; heart failure; mitral valve
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Background: For over 50 years, surgical septal myectomy has been the preferred treatment for drug-refractory heart failure symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM). Over this time in the United States, the majority of myectomy operations have been performed in a small number of select referral centers. Methods: We have taken the opportunity to report results from the relatively new Tufts HCM Center and surgical program, incorporated 13 years ago, during which 507 myectomies (52 +/- 14 years of age; 56% male) were performed by one cardiothoracic surgeon, Dr. Hassan Rastegar. Results: Resting left ventricular (LV) outflow gradients were reduced from 56 +/- 42 mmHg preoperatively to 1.2 +/- 6.8 mmHg on most recent echocardiogram 2.0 +/- 2.5 years after surgery, and 94% of patients showed clinical improvement to NYHA functional class I or II. The first 200 myectomies were performed without mortality or major complications. Among all patients, 30-day mortality rate was 0.8%. Over follow-up of 3.2 +/- 2.8 years, 11 patients died (four due to HCM causes) with long-term survival after myectomy of 94% at 5 years (95% CI: 89-96%) and 91% at 10 years (95% CI: 84-95%), which did not differ from the age-and gender-matched general U. S. population (log-rank P=0.9). Conclusions: This experience demonstrates that, with the appropriate support, new HCM surgical programs can provide patients successful relief of outflow obstruction, extended longevity and restored of quality of life.
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