Journal
ONCOLOGY LETTERS
Volume 13, Issue 4, Pages 2649-2655Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.5787
Keywords
lentivirus; RNA interference; tripartite motif containing 68; proliferation; colorectal cancer
Categories
Funding
- National Natural Science Foundation of China [81172307]
- Youth Foundation of Chengdu Military General Hospital [2016KC06, 41732C116]
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Colorectal cancer is one of the most common types of cancer worldwide. Previous studies have revealed that certain members of tripartite motif (TRIM) proteins are involved in carcin ogenesis regulation, but little is known about the function of TRIM68 in human colorectal cancer. To investigate the role of TRIM68 in colorectal cancer SW1116 and HCT116 cell lines, the present study conducted lentivirus-mediated knockdown against TRIM68 and demonstrated that depletion of TRIM68 notably inhibits colorectal cancer cell proliferation and colony formation ability. Cell cycle arrest in the G0/G1 phase and cycle accumulation in sub-G1 phase provided evidence that TRIM68 may participate in the regulation of colorectal cancer tumorigenesis. The results revealed the significant role of TRIM68 in regulating colorectal cancer cell mitosis and indicated that TRIM68 may be a promising therapeutic target.
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