Journal
ONCOLOGY LETTERS
Volume 14, Issue 2, Pages 1379-1386Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.6319
Keywords
long non-coding RNA; expression profiles; cervical cancer
Categories
Funding
- Medical and Health Project of Zhejiang Province [2016KYA137]
- Wenzhou Public Welfare Science and Technology Project [Y20140707]
- Incubation Project of the First Affiliated Hospital of Wenzhou Medical University [FHY2014009]
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Cervical cancer (CC), one of the most common types of cancer of the female population, presents an enormous challenge in diagnosis and treatment. Long non-coding (lnc) RNAs, non-coding (nc) RNAs with length >200 nucleotides, have been identified to be associated with multiple types of cancer, including CC. This class of nc transcripts serves an important role in tumor suppression and oncogenic signaling pathways. In the present study, the microarray method was used to obtain the expression profile of lncRNAs and protein-coding mRNAs and to compare the expression of lncRNAs between CC tissues and corresponding adjacent non-cancerous tissues in order to screen potential lncRNAs for associations with CC. Overall, 3356 lncRNAs with significantly different expression pattern in CC tissues compared with adjacent non-cancerous tissues were identified, while 1,857 of them were upregulated. These differentially expressed lncRNAs were additionally classified into 5 subgroups. Reverse transcription quantitative polymerase chain reactions were performed to validate the expression pattern of 5 random selected lncRNAs, and 2lncRNAs were identified to have significantly different expression in CC samples compared with adjacent non-cancerous tissues. This finding suggests that those lncRNAs with different expression may serve important roles in the development of CC, and the expression data may provide information for additional study on the involvement of lncRNAs in CC.
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