Journal
ONCOLOGY LETTERS
Volume 14, Issue 6, Pages 7467-7472Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.7153
Keywords
Ganoderma lucidum; triterpenes; prostate cancer; metastasis; apoptosis
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Funding
- Fundamental Research Funds for the Central Universities [21615498]
- Medical Scientific Research Foundation of Guangdong Province [A2015463]
- Administration of Traditional Chinese Medicine of Guangdong Province, China [20151186]
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Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant and liver protective effects. G. lucidum has been associated with prostate cancer cells. G. lucidum extracts contain numerous bioactive components; however, the exact functional monomer is unknown and the role of triterpenes from G. lucidum (GLT) in prostate cancer remain obscure. The present study investigated the effects of GLT on cell viability, migration, invasion and apoptosis in DU-145 human prostate cancer cells. The results demonstrated that a high dose (2 mg/ml) of GLT inhibits cell viability in a dose-and time-dependent manner by the regulation of matrix metalloproteases. Furthermore, GLT induced apoptosis of DU-145 cells. In general, GLT exerts its effect on cancer cells via numerous mechanisms and may have potential therapeutic use for the prevention and treatment of cancer.
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