Journal
CHEMIE INGENIEUR TECHNIK
Volume 89, Issue 8, Pages 1006-1016Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cite.201700017
Keywords
Continuous manufacturing; Discharge of material; Process simulation; Rotary tablet press; Turret speed
Categories
Funding
- Austrian COMET Program
- Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT)
- Austrian Federal Ministry of Economy, Family and Youth (BMWFJ)
- State of Styria (Styrian Funding Agency SFG) as a part of the European Consortium for Continuous Pharmaceutical Manufacturing (ECCPM)
- Bayer AG
- AstraZeneca
- UCB
- Maag Automatik GmbH
- Siemens AG
- GEA
- Ghent University
- University of Eastern Finland
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In a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown of the tablet press. Various operating scenarios were simulated and the influence of turret speed on the tablet properties was experimentally investigated. Changes in the turret speed alter the critical process parameters dwell time and die filling time. Their influence was evaluated using two model formulations with different compaction behavior.
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