Journal
EPIGENOMICS
Volume 9, Issue 8, Pages 1105-1122Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0009
Keywords
DNA methylation; epigenetics; MeDIP-chip; microarray; MRL/MpJ; regeneration; wound healing
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Funding
- National Science Centre of Poland [DEC-2011/01/B/NZ2/05352]
- National Centre for Research and Development of Poland [STRATEGMED1/235077/9/NCBR/2014]
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Aim: We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials & methods: Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results & conclusion: A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified. In the ear pinnae, the DMRs were enriched in genes associated with development, inflammation and apoptosis, and in binding sites of transcriptional modulator Smad1. Several DMRs overlapped previously mapped quantitative trait loci of regenerative capability. The results suggest potential epigenetic determinants of regenerative phenomenon.
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