Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 7, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00422-17
Keywords
Campylobacter jejuni; DNA gyrase; cmeABC; fluoroquinolone resistance
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Funding
- Chinese Key Research and Development Plan [2016YFD0501305]
- Chinese Special Fund for Agro-scientific Research in the Public Interest [201303044]
- China Agriculture Research System [CARS-42-G11]
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Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increases the expression of cmeABC and contributes to the high fluoroquinolone resistance.
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