Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 4, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2017.1288678
Keywords
ENTPD5; metastasis; mutant p53; N-glycosylation; protein folding
Categories
Funding
- DFG (German Research Foundation)
- European Research Council
- Bundesministerium fur Bildung und Forschung
- Rhon Klinikum AG
- DZL (German Center for Lung Research)
- Deutsche Jose Carreras Leukamie-Stiftung
- Deutsche Krebshilfe
- LOEWE
- Von-Behring-Rontgen-Stiftung
- Universitatsklinikum Giessen und Marburg
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Mutations in cancer abolish normal tumor suppressive functions of tumor protein p53 (TP53, best known as p53) and convert it into an oncogene. We recently reported the identification of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) as a transcriptional target of mutant p53 that enhances folding of N-glycosylated proteins required for cancer cell migration, invasion, and metastasis.
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