Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 4, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1198299
Keywords
Autophagy; cell motility; metastasis; paxillin; Src
Categories
Funding
- NIH [RO1 CA 162405, T32 GM007281, T32 CA009594]
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Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.
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