Journal
CORTEX
Volume 93, Issue -, Pages 178-192Publisher
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2017.05.020
Keywords
Parkinson's disease; Aging; Functional fMRI; Frontostriatal circuitry; Attentional set-shifting; Learning
Funding
- Wellcome Trust [WT072378MA]
- Canada Excellence Research Chair award
Ask authors/readers for more resources
Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit remain unclear. In this study, an fMRI-pptimised variant of a classic paradigm for assessing attentional control (Hampshire and Owen 2006) was used to contrast activity in dissociable executive circuits in early-stage PD patients and controls. The results demonstrated that the neural basis of the executive performance impairments in PD is accompanied by hypoactivation within the striatum, anterior cingulate cortex (vACC), and inferior frontal sulcus (IFS) regions. By contrast, in aging it is associated with hypoactivation of the anterior insula/inferior frontal operculum (Al/FO) and the pre-supplementary motor area (preSMA). Between group behavioural differences were also observed; whereas normally aging individuals exhibited routine-problem solving deficits, PD patients demonstrated more global task learning deficits. These findings concur with recent research demonstrating model-based reinforcement learning deficits in PD and provide evidence that the AI/FO and IFS circuits are differentially impacted by PD and normal aging. (C) 2017 The Authors. Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available