Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 32, Pages 9326-9330Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703332
Keywords
DNA melting; fluorescent probes; nanoheaters; single particles; single-walled carbon nanotubes
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Funding
- Office of Naval Research [N000141110465]
- NIH/NIGMS [R01GM114167]
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Optical excitation of nanostructures is known to induce local heating, a phenomenon that has been intensely exploited for drug release, gene delivery, cancer thermotherapy, and energy harvesting. However, the effect is typically small requiring collective heating of a large concentration or aggregates of particles. Herein, we show that optical excitation of individual semiconducting single-walled carbon nanotubes triggers strongly localized heating adequate to melt non-covalently attached double-stranded oligonucleotides in solution. In contrast to conventional thermal dehybridization, this optically triggered DNA melting occurs at a solution temperature that is 22 degrees C lower than the DNA melting temperature. This unexpectedly large localized optical heating effect provides important new insights to design selective optical nano-heaters at the single particle level.
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