Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 4, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1264351
Keywords
Autophagy receptor; cancer; endoplasmic reticulum; ER-phagy; LIR; oncogene; recovER-phagy; SEC62; selective autophagy; TLOC1; tumor
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Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for understanding the phenotypes and treat SEC62high tumors, which are characterized by high ER stress tolerance.
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