Journal
NEOPLASMA
Volume 64, Issue 4, Pages 526-534Publisher
AEPRESS SRO
DOI: 10.4149/neo_2017_406
Keywords
miR-361-5p; FOXM1; EMT; lung cancer
Categories
Funding
- National Natural Science Foundation of China [81372843, 81502518]
Ask authors/readers for more resources
Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available