Journal
CANCER LETTERS
Volume 402, Issue -, Pages 16-31Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.05.010
Keywords
Bee venom; Melittin; Melittin conjugates; Cancer management; Anti-cancer effects
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Funding
- Egyptian Ministry for Higher Education
- ACS [120038-MRSG-11-019-01-CNE]
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Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL. (C) 2017 Elsevier B.V. All rights reserved.
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